Table 3.
Results of laboratory tests before and after medication use according to medication treatment groups.
| Total N | No treatment | With treatment | |||
|---|---|---|---|---|---|
| Mean/n | SD/Row/% | Mean/n | SD/Row% | ||
| Creatinine (mg/dL) | |||||
| allopurinol or febuxostat | 762 | 1.81 | 2.01 | 1.84 | 2.18 |
| allopurinol or febuxostat plus fenofibrate | 68 | 1.21 | 0.29 | 1.26 | 0.27 |
| BUN (mg/dL) | |||||
| allopurinol or febuxostat | 760 | 22.23 | 17.22 | 23.07 | 18.6 |
| allopurinol or febuxostat plus fenofibrate | 68 | 15.54 | 8.04 | 15.24 | 5.07 |
| AST (IU/L) | |||||
| allopurinol or febuxostat | 760 | 28.89 | 22.33 | 30.15 | 21.31 |
| allopurinol or febuxostat plus fenofibrate | 69 | 33.58 | 22.14 | 33.09 | 17.6 |
| ALT (U/L) | |||||
| allopurinol or febuxostat | 759 | 35.79 | 44.0 | 35.72 | 30.15 |
| allopurinol or febuxostat plus fenofibrate | 67 | 46.16 | 39.86 | 40.09 | 27.23 |
| AST* | |||||
| allopurinol or febuxostat | 698 | 11 | 1.6 | 16 | 2.3 |
| allopurinol or febuxostat plus fenofibrate | 67 | 3 | 4.5 | 1 | 1.5 |
| ALT* | |||||
| allopurinol or febuxostat | 698 | 26 | 3.7 | 31 | 4.4 |
| allopurinol or febuxostat plus fenofibrate | 67 | 6 | 9.0 | 3 | 4.5 |
| Bilirubin | |||||
| allopurinol or febuxostat | 755 | 0.73 | 0.37 | 0.76 | 0.41 |
| allopurinol or febuxostat plus fenofibrate | 68 | 0.71 | 0.35 | 0.68 | 0.25 |
| Total cholesterol | |||||
| allopurinol or febuxostat | 758 | 181.0 | 42.0 | 180.96 | 39.83 |
| allopurinol or febuxostat plus fenofibrate | 68 | 203.2 | 43.7 | 190.81 | 38.15 |
| HDL cholesterol | |||||
| allopurinol or febuxostat | 430 | 42.91 | 12.18 | 42.91 | 12.18 |
| allopurinol or febuxostat plus fenofibrate | 56 | 39.13 | 9.99 | 39.13 | 9.99 |
| LDL cholesterol | |||||
| allopurinol or febuxostat | 187 | 113.71 | 38.41 | 109.49 | 34.26 |
| allopurinol or febuxostat plus fenofibrate | 23 | 120.04 | 39.71 | 102.27 | 42.5 |
| Triglyceride | |||||
| allopurinol or febuxostat | 469 | 196.41 | 106.76 | 187.71 | 109.39 |
| allopurinol or febuxostat plus fenofibrate | 62 | 418.42 | 190.01 | 316.17 | 185.15 |
| Glucose | |||||
| allopurinol or febuxostat | 754 | 110.41 | 33.86 | 106.55 | 28.27 |
| allopurinol or febuxostat plus fenofibrate | 68 | 106.68 | 27.09 | 105.39 | 27.03 |
SD: standard deviation; BUN: blood urea nitrogen; AST: aspartate aminotransferase; ALT: alanine aminotransferase; HDL: high density lipoprotein; LDL: low density lipoprotein.
*The number and proportion of patients who exceed three times of the maximum normal range before and after medication.