FIGURE 2.
m6A RNA modification is mediated by writers, readers and erasers. Mechanisms of RNA modification (writing), recognition and erasure are highly conserved. The methyltransferase complex is composed of multiple proteins and methylates the mRNA. Methylation occurs simultaneously with transcription and is recognized by the reader protein, which, in turn, recruits other proteins such as the splicing machinery. The reader may also protect against demethylation by physically blocking access of the demethylase enzyme, or the m6A methylation mark may be erased by a demethylase