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. Author manuscript; available in PMC: 2018 Nov 13.
Published in final edited form as: Cell Rep. 2018 Sep 25;24(13):3433–3440.e4. doi: 10.1016/j.celrep.2018.08.072

Figure 2. Regulation of NMDAR Function at TC Synapses onto Adult V1 L4 Neurons following Deafening.

Figure 2.

(A). Left: NMDA/AMPA ratio measurements for the NR and DF groups (open circles represent individual cells; NR = 0.49 ± 0.045, 4 mice; DF = 0.43 ± 0.067, 5 mice; t test, N.S. p = 0.5173). Right: averaged example traces for an NR cell (blue) and DF cell (red) normalized to the AMPAR component in NR. The AMPAR component was measured at the peak recorded at −80 mV, while the NMDAR component was measured 70 ms after the onset of the compound EPSC recorded at +40 mV.

(B). Left: weighted decay time constant (Tw) for a pharmacologically isolated NMDAR current measured at +40 mV for the NR and DF groups (open circles represent individual cells; NR = 89.31 ± 11.97 ms, 4 mice; DF = 63.93 ± 6.3 ms, 3 mice; t test, N.S. p = 0.0961). Right: averaged NMDAR responses for the NR (blue) and DF (red) groups normalized to the maximum amplitudes.

Bar graphs: mean ± SEM.