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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Sep 29;28(22):3529–3533. doi: 10.1016/j.bmcl.2018.09.037

Scheme 2.

Scheme 2.

Synthesis of C2 non-substituted quinoline analogs. Reagents and conditions: a) TsOH.H2O, toluene, reflux then Ph2O, 250 oC, 83%; b) NaOH, H2O/THF, 90%; c) Ph2O, 250 oC, 75%; d) XPhos-Pd-G2, 13, Na2CO3, dioxane/H2O, 50%; e) Tf2O, Et3N, CH2Cl2, 66%; f) Pd(PPh3)4, R-B(OH)2, Et3N, dioxane, 100 oC, 8–93%.