. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Bioorg Med Chem Lett. 2018 Sep 29;28(22):3529–3533. doi: 10.1016/j.bmcl.2018.09.037

Table 1.

C4 SAR graphic file with name nihms-1509408-f0012.jpg

Compd	R	Mtb H37Rv MIC₉₀ (μM)	Solubility¹⁰ (μM)

15a	2-ClPh	0.3	n.d.
15b	3-ClPh	1.5	1
15c	4-ClPh	>80	n.d.
15d	2-CNPh	2.5	24
15e	2-Et₂NCH₂Ph	2.5	59
15f	2-HO₂CPh	40	222
15g	2-H₂NC(O)Ph	20	n.d.
15h	2-Cl-3-MeOPh	10	2
15i	2,6-diMe-Ph	5	n.d.
15j	3-pyridyl	5	209
15k		2.5	169
15l		2.5	1
15m		2.5	243
15n		2.5	>230