. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Bioorg Med Chem Lett. 2018 Sep 29;28(22):3529–3533. doi: 10.1016/j.bmcl.2018.09.037

Table 2.

In vitro ADME parameters of 15n

	Mouse	Human

Plasma protein binding (%) ^a	92.8	95.2
Microsomal stability (% remaining at 60 min) ^a	<5	11.6

All experiments were performed at least twice in duplicate, and data reported are mean values.