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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Chem Phys Lipids. 2018 Sep 25;216:142–151. doi: 10.1016/j.chemphyslip.2018.09.013

Figure 1. Ceramide pools and their metabolic connection.

Figure 1.

Biosynthetic pathway and metabolism of ceramide (black) – see main text for pathway description. The figure shows metabolizing enzymes (blue) and identified bioactive pools of ceramide (purple). SPT- Serine Palmotoyl Transferase; CerS- (dihydro-)Ceramide Synthase; Cer-DES- Dihydroceramide Desaturase; SMS- Sphingomyelin Synthase; nSMase- Neutral Sphingomyelinase; aSMase- Acid Sphingomyelinase; s-secreted form; aCDase- Acid Ceramidase.