Table 2:

Currently FDA Approved Direct Oral Anticoagulant Drugs and Doses Across the Spectrum of Kidney DIsease

FDA Approved DOAC Dosing Table for Treatment of Atrial Fibrillation based on Creatinine Clearance
	Dabigatran	Rivaroxaban	Apixaban	Edoxaban
CrCl > 90ml/min		20 mg daily	5mg twice daily	Not
	150 mg twice daily		2.5mg twice daily if > 2 risk factors*	Approved for CrCl > 95
50 < CrCl < 90				60mg daily
30 < CrCl < 50		15mg daily
15 < CrCl < 30	75mg twice daily			30mg daily
CrCl < 15	Not FDA approved
Dialysis	Not FDA approved			Not FDA Approved

^*Risk Factors:

– Age ≥ 80

– Weight ≤ 60

– Serum Creatinine ≥ 1.5 mg/dL