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. Author manuscript; available in PMC: 2018 Nov 13.
Published in final edited form as: Adv Exp Med Biol. 2018;1066:141–185. doi: 10.1007/978-3-319-89512-3_8

Figure 2: Notch signaling is required for lateral inhibition and lineage decisions during mechanosensory organ development.

Figure 2:

A) Photograph of the fly notum. Large (macrochaetae) and small (microchaetae) are organized in a stereotypical fashion. B) Schematic diagram of a single mechanosensory organ (bristle). C) Schematic diagram representing the development of a single bristle. “N” indicates cells that activate Notch signaling. D-D’) Schematic diagrams of lateral inhibition during the selection of a sensory organ precursor (SOP) cell. In the beginning both cells have the potential to become an SOP. As development progresses, two cells acquire distinct fates through amplification of small differences through transcriptional feedback loops built into the stem. Cells that become the net signal sending cell becomes the SOP (labeled in red), and the net signal receiving cell(s) takes the epithelial cell fate. Panels B and C were adapted and mofidied from [108].