Table 1: List of Drosophila genes discussed in this chapter along with their human homologs, disease association and functions.
Human genes in bold have been linked diseases based on OMIM (https://www.omim.org/). The fly genes that are homologous to these genes are also shown in bold. Fly genes with “?” have mammalian homologs that have been shown to be involved in the Notch pathway but their role in Notch signaling in Drosophila have not been studied or are not clear. See [440–449] to find the full list of genes involved in Arp2/3-WASp, ESCRT, AP-3, HOPS and V-ATPase complexes in Drosophila and human.
| Drosophllo gene (symbol) | Human homolog(s) (OMIM disease #) | Protein Functions |
|---|---|---|
| Notch (N) | NOTCH1 (#109730, #616028), NOTCH2 (#102500, #610205), NOTCH3 (#125310, #130720, #615293), N0TCH4 | Receptor |
| Delta (Dl) | DLL1, DLL3 (#277300), DLL4 (#616589) | Ligand |
| Serrate (Ser) | JAG1 (#118450, #187500), JAG2 | |
| rumi | POGLUT1 (#615696,617232) | Receptor glycosylation |
| O-fucosyltransferase 1 (O-fut1) | POFUT1 (#615327) | |
| Shams | GXYLT1, GXYLT2 | |
| fringe | LFNG (#609813), MFNG, RFNG | |
| EGF-domain O-GlcNAc transferase (Eogt) | EOGT (#615297) | |
| neurolized (neur) | NEURL1, NEURL1B | E3 ligase for ligand |
| mind bomb 1(mib1) | MIB1 (#615092) | |
| Furin1 (Fur1)?, Furin2(Fur2)? | FUR | S1 cleavage |
| kuzbanian (kuz) | ADAM10 (#615537) | S2 cleavage |
| Presenilin (Psn) | PSEN1 (#172700, #600274, #607822, #613694, #613737), PSEN2 (#606889, #613697) | S3 cleavage |
| aph-1 | APH1A, APH1B | |
| nicastrin (nct) | NCSTN (#142690) | |
| pen-2 | PSENEN (#613736) | |
| shibire(shi) | DNM1 (#616346), DNM2 (#160150, #606482, #615368), DNM3 | Receptor and ligand endocytosis |
| Sec15 | EXOCS, EXOC6B | Ligand trafficking |
| Rab11 | RAB11A, RAB11B | |
| Arp2/3 Complex: 8 genes (e.g. Arp2, Arp3) [Ref.440] | Arp2/3Complex: 9genes [Ref.445] | |
| WASp | WAS (#301000), WASL | |
| Ehbp1 | EHBP1 (#611868), EHBP1L | |
| temp | PTAR1 | |
| Numb | NUMB, NUMBL | Receptor trafficking |
| Sanpodo (Spdo) | - | |
| deltex (dx) | DTX1, DTX2, DTX3, DTX3L, DTX4 | |
| supressor of deltex (su(dx)) | ITCH (#613385), WWP1, WWP2 | |
| lethal(2)giant discs 1 (l(2)gd1) | CC2D1A (#608443), CC2D1B | |
| ESCRT complex: 20 genes (e.g. shrub, Vps25) [Ref.441] | ESCRT complex: 30 genes (#114480, #600795, #605387, #614898, #614696) [Ref.446] | |
| AP-3 complex: 4 genes (e.g. carmine (cm), ruby(rb))[Ref.442] | AP-3 complex: 7 genes (#608233, #617050, #617276)) [Ref.447] | |
| HOPS complex: 7 genes (e.g. carnation (car), deep orange (dor)) [Ref .443] | HOPS complex: 8 genes (#208085, #616683, #617303) [Ref.448] | |
| V-ATPase complex: 33 genes (e.g. VhaAC39–1, Vha68–2) [Ref.444] | V-ATPase complex: 23 genes (#124480, #219200, #259700, #267300, #278250, #259700, #616455, #617402, #617403) [Ref .449] | Vesicle acidification |
| Supressor of Hairless (Su(H)) | RBPJ (#614814) | Transcription factor |
| Hairless (H) | - | Corepressor |
| - | SPEN (SHARP/Mint) | |
| - | FHL1 (KyoT2) (#300695, #300696, #300717, #300718) | |
| groucho(gro) | TLE1, TLE2, TLE3, TLE4, TIE5, TLE6 (#616814) | |
| C-terminal Binding Protein (CtBP) | CTBP1, CTBP2 | |
| mastermind (mam) | MAML1, MAML2, MAML3 | Coactivator |
| nejire(nej) | EP300 (#114500, #613684), CREBBP (#180849) | |
| Enhancer of split complex [E(spl)-C): 7 bHLH repressor genes: e.g. E(spl)-m8) | HES1, HES2, HES3, HES4, HES5, HES6, HES7 (#613686) | Target Genes |
| sage? | MESP2 (#608681) | |
| Doc?1, Doc2?, Doc3? | TBX6 (#122600) | |
| Cdk8? | CDK8 | NICD degradation |
| archipelago (ago)? | FBXW7 |