Table 4.
Anthropometric, body composition and REE analysis for FTO rs9939609 A carriers vs TT genotype in MeD and CTR groups
| TT genotype | A carriers | P main effect of FTO rs9939609 | P main effect of diet | P main effect gene-diet interaction | |||
|---|---|---|---|---|---|---|---|
| MeD | CTR | MeD | CTR | ||||
| (n = 40) | (n = 17) | (n = 99) | (n = 32) | ||||
| Weight (kg) | 0.85 | 0.43 | 0.87 | ||||
| Baseline | 79.63 (21.56) | 73.33 (17.26) | 83.29 (22.73) | 78.73 (15.87) | |||
| Change | − 3.41 (6.47) | − 1.27 (3.89) | − 2.25 (11.79) | − 0.62 (1.26) | |||
| BMI | 0.92 | 0.33 | 0.81 | ||||
| Baseline | 29.03 (7.39) | 25.74 (3.64) | 30.4 (7.35) | 28.50 (6.03) | |||
| Change | − 1.28 (2.34) | − 0.30 (0.82) | − 0.85 (4.27) | − 0.18 (0.80) | |||
| Neck circumference (cm) | 0.50 | 0.78 | 0.37 | ||||
| Baseline | 40.54 (3.39) | 36.75 (3.28) | 41.03 (4.19) | 36.88 (3.76) | |||
| Change | − 0.60 (0.42) | − 0.40 (0.96) | − 1.09 (2.13) | − 0.07 (1.12) | |||
| Waist circumference (cm) | 0.80 | 0.87 | 0.86 | ||||
| Baseline | 88.17 (19.18) | 86.81 (11.66) | 94.14 (17.25) | 87.7 (12.72) | |||
| Change | − 1.10 (3.03) | − 0.78 (1.82) | − 1.91 (7.55) | − 1.10 (2.34) | |||
| Abdomen circumference (cm) | 0.87 | 0.97 | 0.28 | ||||
| Baseline | 104.92 (18) | 93.74 (9.66) | 107.49 (15.9) | 99.48 (14.6) | |||
| Change | − 0.80 (1.48) | − 1.04 (3.46) | − 3.73 (6.51) | − 1.13 (2.89) | |||
| Hip circumference (cm) | 0.93 | 0.70 | 0.76 | ||||
| Baseline | 103.8 (11.16) | 102.72 (7.68) | 107.68 (13.01) | 107.67 (12.13) | |||
| Change | − 1.90 (4.04) | − 1.38 (3.55) | − 2.51 (3.93) | − 1.44 (3.29) | |||
| WHR | 0.80 | 0.89 | 0.89 | ||||
| Baseline | 0.84 (0.12) | 0.84 (0.08) | 0.87 (0.12) | 0.82 (0.08) | |||
| Change | 0.00 (0.02) | 0.00 (0.03) | 0.00 (0.07) | 0.00 (0.03) | |||
| R | 0.10 | 0.98 | 0.87 | ||||
| Baseline | 533.35 (88.18) | 545.31 (80.2) | 484.66 (107.09) | 507.77 (78.38) | |||
| Change | − 3.00 (22.26) | 0.24 (33.1) | 20.11 (59.77) | 25.91 (42.27) | |||
| Xc | 0.38 | 0.32 | 0.38 | ||||
| Baseline | 55.8 (11.45) | 58.81 (8.83) | 54.98 (15.84) | 54.84 (10.33) | |||
| Change | 0.00 (4.76) | − 4.53 (6.69) | − 2.2 (10.33) | − 2.13 (8.13) | |||
| PA | 0.73 | 0.45 | 0.58 | ||||
| Baseline | 6.23 (1.06) | 6.24 (1.22) | 6.62 (1.54) | 6.22 (1.07) | |||
| Change | 0.10 (0.34) | − 0.40 (0.79) | − 0.47 (1.57) | − 0.53 (0.94) | |||
| BCM (kg) | 0.17 | 0.91 | 0.94 | ||||
| Baseline | 27.29 (6.39) | 28.95 (8.13) | 31.99 (9.68) | 29.66 (6.28) | |||
| Change | − 0.33 (0.98) | − 0.54 (3.51) | − 2.62 (7.63) | − 2.75 (4.26) | |||
| Na/K | 0.64 | 0.66 | 0.53 | ||||
| Baseline | 0.97 (0.12) | 0.98 (0.13) | 0.91 (0.18) | 0.96 (0.13) | |||
| Change | 0.03 (0.1) | 0.06 (0.1) | 0.06 (0.17) | − 0.12 (0.63) | |||
| TBW (L) | 0.02* | 0.48 | 0.47 | ||||
| Baseline | 38.36 (8.55) | 38.54 (8.94) | 41.76 (10.99) | 39.81 (6.57) | |||
| Change | − 0.83 (1.63) | 0.70 (3.04) | − 1.88 (4.35) | − 1.75 (3.28) | |||
| ECW (L) | 0.81 | 0.43 | 0.56 | ||||
| Baseline | 17.23 (4.06) | 17.22 (3.9) | 18.01 (5.27) | 17.89 (3.04) | |||
| Change | − 0.25 (1.5) | 2.00 (3.26) | 2.16 (6.74) | 2.42 (4.07) | |||
| ICW (L) | 0.65 | 0.92 | 0.81 | ||||
| Baseline | 21.12 (5.16) | 17.22 (3.9) | 23.75 (6.97) | 20.59 (4.05) | |||
| Change | − 0.25 (0.74) | − 0.54 (1.8) | − 1.89 (4.85) | − 0.95 (1.79) | |||
| BCMI | 0.70 | 0.91 | 0.52 | ||||
| Baseline | 12.77 (7.02) | 10.11 (1.96) | 13.9 (8.08) | 10.56 (1.94) | |||
| Change | − 0.10 (0.34) | − 0.34 (1) | − 2.40 (6.81) | − 0.85 (1.23) | |||
| Android Bfat (%) | 0.60 | 0.09 | 0.93 | ||||
| Baseline | 44.92 (12.45) | 37.34 (8.78) | 44.88 (12.77) | 39.79 (12.61) | |||
| Change | − 4.52 (6.01) | − 1.00 (2.16) | − 2.96 (4.64) | 0.15 (1.7) | |||
| Gynoid Bfat (%) | 0.70 | 0.04* | 0.32 | ||||
| Baseline | 43.51 (10.63) | 36 (7.85) | 41.8 ( 77(11.76) | 39.07 (9.37) | |||
| Change | − 2.94 (5.14) | 0.03 (1.26) | − 1.67 (3.51) | − 0.42 (1.74) | |||
| TBFat (%) | 0.79 | 0.08 | 0.94 | ||||
| Baseline | 37.92 (9.45) | 33.16 (6.05) | 38.08 (10.34) | 36.14 (9.52) | |||
| Change | − 2.74 (3.45) | − 0.19 (1.14) | − 2.01 (3.65) | 0.31 (0.9) | |||
| Android Bfat (kg) | 0.89 | 0.27 | 0.91 | ||||
| Baseline | 3.02 (1.96) | 2.32 (1.08) | 3.3 (2.17) | 2.78 (1.39) | |||
| Change | − 0.47 (0.53) | − 0.04 (0.27) | − 0.45 (1.18) | − 0.12 (0.63) | |||
| Gynoid Bfat (kg) | 0.49 | 0.84 | 0.40 | ||||
| Baseline | 5.57 (2.19) | 4.37 (1.45) | 5.49 (2.58) | 5.78 (1.79) | |||
| Change | − 0.62 (0.85) | − 0.46 (1.25) | − 0.36 (2.82) | − 0.94 (2.25) | |||
| TBFat (Kg) | 0.06 | 0.00* | 0.04* | ||||
| Baseline | 31.34 (14.5) | 21.32 (8.66) | 32.85 (15.56) | 23.24 (12.11) | |||
| Change | − 3.59 (4.78) | 1.93 (5.54) | − 3.97 (6.97) | 6.11 (9.60) | |||
| Android BLean (kg) | 0.97 | 0.32 | 0.12 | ||||
| Baseline | 3.32 (1.01) | 3.31 (0.86) | 3.2 (0.91) | 3.31 (0.62) | |||
| Change | − 0.22 (0.87) | − 0.08 (0.15) | 0.11 (0.6) | − 0.08 (0.27) | |||
| Gynoid BLean (kg) | 0.49 | 0.92 | 0.91 | ||||
| Baseline | 6.77(1.86) | 7.24(2.16) | 6.79(1.9) | 7.08(1.26) | |||
| Change | − 0.20(1.54) | − 0.18(0.31) | − 0.56(5.66) | 0.01(0.33) | |||
| TBLean (kg) | 0.92 | 0.63 | 0.87 | ||||
| Baseline | 47.67(11.77) | 46.47(11.84) | 47.86(11.37) | 47.28(8.87) | |||
| Change | − 1.23(6.82) | − 0.53(1.05) | − 0.56(5.66) | − 0.61(2.08) | |||
| REE | 0.77 | 0.27 | 0.49 | ||||
| Baseline | 1639.92 (409.68) | 1664.96 (217.89) | 1628.13 (347.37) | 1583.46 (313.51) | |||
| Change | − 48.13 (327.01) | − 31.44 (140.89) | − 44.01 (220.32) | − 7.49 (34.75) | |||
Relationship between FTO rs9939609 A carriers and TT genotype in body composition and metabolism, according to MeD and CTR groups. Statistical significance (*) were given to results with p < 0.05 through GLM analysis. BMI body mass index, WHR waist hip ratio, R resistance, Xc reactance, PA phase angle, HYDR hydration, NA/K sodium–potassium exchange, TBW total body water, ECW extracellular water, ICW intracellular water, BFat body fat, TBFat total body fat, BLean body lean, TBLean total body lean, REE resting energy expenditure