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. 2018 Nov 12;18:1087. doi: 10.1186/s12885-018-4989-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The antitumor efficacy against SW480 tumor xenografts. (a) Tumor size was measured every 3 d, and tumor volume was calculated. Tumor size decreased significantly in the KGHV500 combined with CIK treatment group. (b) There were more apoptotic tumor cells found in the KGHV500 combined with CIK cells group than in any other group (green: TUNEL, blue: DAPI × 1000). (c) The expression of caspase-3, caspase-7, p53, Bcl-2 and survivin genes in adenovirus or CIK cell-treated group detected by Q-PCR. p53, caspase-3 and caspase-7 gene expression was increased by KGHV500 combined with CIK cells treatment, and Bcl-2 and survivin gene expression was decreased by KGHV500 combined with CIK cells treatment