Table 2.

Pharmacokinetic parameters of LZD after intravenous (i.v.) and oral (p.o.) administration with and without RFP

			Control	with RFP
i.v.	AUC0–12	μg/mL ▪ h	232 ± 61	194 ± 54
	Cmax	μg/mL	72.5 ± 17.8	65.9 ± 15.2
	ke	h−1	0.292 ± 0.041	0.329 ± 0.048
	t1/2	h	2.41 ± 0.33	2.14 ± 0.29
	CLtot	L/h/kg	0.210 ± 0.064	0.253 ± 0.078
	Vd	L/kg	0.693 ± 0.156	0.758 ± 0.262
p.o.	AUC0–12	μg/mL ▪ h	280 ± 64	145 ± 103*
	Cmax	μg/mL	48.0 ± 18.1	22.1 ± 12.1*
	F	%	88.3 ± 20.1	45.8 ± 32.4*

Values are mean ± SD of three to six rats. *p < 0.05

AUC_0–12 area under the concentration-time curve from time 0 to 12 h, C_max maximum concentration, k_e elimination rate constant, t_1/2 half-life, CL_tot total clearance, V_d volume of distribution, F bioavailability