Table 2.

The number of neutrophils in the inter-alveolar septa of the lung, semiquantitative evaluation of pathological changes in the liver, and ALT and AST enzyme activities in the serum of mature female and male Wistar rats on the first day after the administration of low- or high-dose LPS

Sex	Group	Number of neutrophils in the inter-alveolar septa of the lung, 25,000 µm2	Dystrophic and necrotic change index in hepatocytes, points	ALT, U/L	AST, U/L
Females	Control1	1.6 (1.4–1.9)n=10	1.5 (1.0–2.5)n=10	57 (54–92)n=7	143 (142–180)n=7
	LPS 1.5 mg/kg2	5.7 (4.7–7.6)n=9	3.0 (2.0–3.0)n=7	20 (16–31)n=9	39 (39–68)n=6
	LPS 15 mg/kg3	23.6 (14.6–28.7)n=9	3.0 (3.0–4.0)n=6	736 (96–2141)n=5	771 (160–2652)n=5
Males	Control4	1.4 (1.4–2.0)n=8	1.0 (0.5–1.5)n=5	38 (30–41)n=5	72 (61–76)n=8
	LPS 1.5 mg/kg5	10.3 (8.1–13.9)n=6	2.0 (2.0–2.2)n=5	53 (46–69)n=6	93 (77–116)n=5
	LPS 15 mg/kg6	27.8 (24.0–32.6)n=7	3.5 (2.0–4.0)n=7	297 (145–398)n=5	425 (188–604)n=5
Statistical significance of differences (P)		0.000011–2 0.000011–3 0.0092–3 0.0034–5 0.00034–6 0.00075–6 0.0022–5	0.0031–2 0.0213 0.012–3 0.0054–5 0.014–6 0.015–6	0.021–2 0.011–3 0.0012–3 0.074–5 0.024–6 0.0015–6	0.021–2 0.011–3 0.0012–3 0.034–5 0.024–6 0.0015–6
F-value		170	300	6.5	11.4

Notes: Superscript 1-6 indicates the group number. Superscripts n=# is the number of observations in the group. Data shown as median (interquartile range).

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; LPS, lipopolysaccharide; Me, median.