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The challenges of conventional antimicrobial agents against Staphylococcus aureus infections
| Antibiotic | Challenge |
|---|---|
| β-lactams | Poor permeability, causing resistance |
| Aminoglycosides | Hardly penetrate within cell, invalid to small colony variants |
| Fluoroquinolones | Poor intracellular accumulation |
| Macrolides | Poor retention within cell |
| Vancomycin | Instability, low permeability for tissue |
