Table 6.

Minimum tests to be performed during monitoring of the patient with PID and respiratory symptoms

TESTS	N (Composition of panel)	Votes in agreement (%)	Degree of agreement
Patient visit every 6–12 months.	34 (AI, AP)	91.2	Consensus
Immunological studies (complete blood count, biochemistry with LDH and Igs) every 6–12 months.	34 (AI, AP)	91.2	Consensus
In the event of RT with gammaglobulins, IgG trough values must be measured more frequently, at least during dose adjustment.	34 (AI, AP)	100.0	Unanimity
Respiratory tests:  • Annual lung function tests are recommended every year.  • Spirometry must be performed every 4–6 months in the absence of lung disease.  • The sputum culture must be performed at each visit if patient is expectorating and in case of any exacerbation.	9 (AP, PP)	100.0	Unanimity
Lung CT every 2–3 years if the patient has pulmonary involvement and every 5 years otherwise. Radiation must be minimized in case of radiosensitive ID.	9 (AP, PP)	100.0	Unanimity
Extrapulmonary tests should be performed according to the patient’s symptoms or manifestations.	43 (AI, PI, AP, PP)	97.7	Consensus

AI: adult immunologists; AP: adult pulmonologists; ID: immunodeficiency; Ig: immunoglobulins; LDH: lactate dehydrogenase; PI: pediatric immunologists; PID: primary immunodeficiency disease; PP: pediatric pulmonologists; RT: replacement therapy