Table 4. Comparison of studied data according to autoimmune regulator (AIRE) gene genotypes in all rheumatoid arthritis (RA) cases.
| RA | P | |||
|---|---|---|---|---|
| CC (n = 156) | CT (n = 109) | TT (n = 33) | ||
| Age (years; mean±SD) | 54.48±15.95 | 54.93±15.48 | 53.45±13.42 | 0.891 |
| Males (n, %) | 73 (46.8%) | 51 (46.8%) | 10 (30.3%) | 0.199 |
| Females (n, %) | 83 (53.2%) | 58 (53.2%) | 23 (69.7%) | |
| Family history (n, %) | 39 (25.0%) | 32 (29.4%) | 5 (15.2%) | 0.255 |
| Onset (years; median±SD) | 45.47±12.72 | 45.91±13.11 | 43.91±10.16 | 0.728 |
| Morning stiffness (n, %) | 0.557 | |||
| 0 | 29 (18.6%) | 24 (22.0%) | 7 (21.2%) | |
| <1 hour | 93 (59.6%) | 59 (54.1%) | 15 (45.5%) | |
| >1 hour | 34 (21.8%) | 26 (23.9%) | 11 (33.3%) | |
| Deformities (n, %) | 57 (36.5%) | 46 (42.2%) | 9 (27.3%) | 0.278 |
| ESR (median±SD) | 34.15±21.92 | 32.70±21.52 | 36.82±23.20 | 0.628 |
| Positive CRP (n, %) | 91 (58.3%) | 70 (64.2%) | 22 (66.7%) | 0.504 |
| Positive RF (n, %) | 127 (81.4%) | 86 (78.9%) | 27 (81.8%) | 0.862 |
| Positive anti-CCP (n, %) | 88 (56.45%) | 56 (51.4%) | 21 (63.6%) | 0.431 |
| Tender joints (median±SD) | 9.22±5.99 | 7.48±5.49 | 10.06±5.83 | 0.020 |
| Swollen joints (median±SD) | 10.42±5.66 | 10.19±5.52 | 9.58±5.15 | 0.727 |
| DAS (median±SD) | 4.33±1.57 | 4.39±1.70 | 4.32±1.53 | 0.946 |
ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; RF: rheumatoid factor; CCP: cyclic citrullinated peptide; DAS: disease activity score in 28 joints. Statistical analyses were carried out with one-way ANOVA and the chi-squared test.