Fig. 2.
Stromal FAP promotes the proliferation, migration, and invasion abilities of SGC7901. In advance, SGC-7901 cells had been cocultured with HELF (SH group), HELFNC cells (SN group) and HELFFAP cells (SF group) for 72 h, respectively. a Exogenous FAP promotes SGC7901 proliferation in dose-dependent manner. b Exogenous FAP promotes SGC7901 migration in dose-dependent manner. c Exogenous FAP promotes SGC7901 invasion in dose-dependent manner. d Cell viability was determined by CCK8 assay. SGC7901 cells in SF group were promoted to proliferate. e Clone formation assay of SGC7901 cells in SF and SN groups. f Western blot assay indicated that the expression of PCNA and MMP9 in SF group was highest. g Wound healing assay indicated that the width of injury was lower in SF group in 24 h. h Cell migration and invasion abilities were determined by Transwell assay. The number of migrated and invasive SGC7901 cells in SF group was much higher than that in SN group