Table 2.
Univariate and multivariate Cox regression analyses of the risk genes for non-small cell lung cancer brain metastasis
| Factorsa | HR | 95% CI | P value |
|---|---|---|---|
| Univariate analysis | |||
| BMI1 | 0.58 | 0.29–1.16 | 0.124 |
| POU5F1 | 0.75 | 0.38–1.47 | 0.397 |
| KLF4 | 1.11 | 0.57–2.18 | 0.757 |
| SMO | 0.86 | 0.43–1.68 | 0.650 |
| JAG1 | 0.85 | 0.43–1.67 | 0.634 |
| SPARC | 1.44 | 0.73–2.84 | 0.292 |
| ST6GALNAC5 | 1.90 | 0.95–3.81 | 0.071 |
| SNAI1 | 1.89 | 0.96–3.74 | 0.066 |
| TNF | 1.23 | 0.63–2.41 | 0.545 |
| CXCR5 | 0.77 | 0.39–1.51 | 0.448 |
| GFAP | 1.00 | 0.51–1.96 | 0.995 |
| DYNC1LI2 | 1.13 | 0.58–2.21 | 0.729 |
| MMP3 | 1.21 | 0.62–2.37 | 0.579 |
| CDH2 | 1.87 | 0.94–3.71 | 0.073 |
| EGFR | 0.65 | 0.33–1.28 | 0.212 |
| VCAN | 1.50 | 0.76–2.97 | 0.247 |
| HGF | 0.76 | 0.39–1.50 | 0.427 |
| CTNNB1 | 0.76 | 0.39–1.50 | 0.428 |
| CXCR4 | 1.46 | 0.74–2.88 | 0.275 |
| KIF3A | 1.47 | 0.74–2.89 | 0.269 |
| GPM6A | 0.70 | 0.36–1.38 | 0.307 |
| HBEGF | 0.95 | 0.48–1.86 | 0.869 |
| CXCL13 | 0.99 | 0.51–1.95 | 0.985 |
| TGFB2 | 0.92 | 0.47–1.80 | 0.803 |
| PLP1 | 0.81 | 0.39–1.69 | 0.568 |
| TWIST1 | 1.45 | 0.74–2.86 | 0.280 |
| PTGS2 | 0.87 | 0.44–1.71 | 0.679 |
| BPTF | 0.77 | 0.39–1.52 | 0.443 |
| FABP7 | 1.92 | 0.96–3.83 | 0.066 |
| GAP43 | 2.12 | 1.09–4.13 | 0.027 |
| PMP2 | 2.12 | 1.05–4.30 | 0.036 |
| UGT8 | 1.23 | 0.63–2.41 | 0.549 |
| GPM6B | 1.00 | 0.51–1.96 | 0.990 |
| FAM107A | 0.62 | 0.31–1.23 | 0.169 |
| IL8 | 1.27 | 0.65–2.49 | 0.492 |
| MMP9 | 1.16 | 0.59–2.27 | 0.668 |
| Multivariate analysisb | |||
| GAP43 | 3.29 | 1.55–7.00 | 0.002 |
| SNAI1 | 1.98 | 1.00–3.95 | 0.051 |
| Grade | 2.08 | 1.00–4.34 | 0.051 |
HR hazard ratio, CI confidence interval
Italic values were statistically significant (P < 0.05)
aFactors were analyzed as categorical variables, and low-expression groups or well-differentiated groups were referred
bGenes whose P values were < 0.1 in univariate analyses and clinicopathologic factors were involved in the multivariate Cox regression analysis, and the Forward LR (based on partial maximum likelihood estimation) was used to identify independent risk factors