Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 12;37:274. doi: 10.1186/s13046-018-0947-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 6 — LAT2 targets glutamine-dependent mTOR activation to regulate apoptosis, glycolysis and chemosensitivity in pancreatic cancer cells. a, b, d, e The percentage of apoptotic MIA PaCa-2 and PANC-1 cells with LAT2 OE was higher than the percentage of apoptotic control cells when the L-glutamine concentration was normal (4 mM); however, glutamine deprivation reversed the decrease in the percentage of apoptotic cells induced by LAT2; glutamine deprivation increased the percentage of apoptotic MIA PaCa-2 and PANC-1 cells. c, f Glutamine deprivation reversed the increase in ECAR and glycoPER induced by LAT2 in MIA PaCa-2 and PANC-1 cells; RAD001 decreased ECAR but not glycoPER in MIA PaCa-2 and PANC-1 cells, regardless of LAT2 expression level. g Exogenous L-glutamine activated the mTOR pathway and upregulated p-mTOR, p-4EBP1 and p21 in MIA PaCa-2 and PANC-1 cells. h Glutamine deprivation promoted the dissociation of LAT2 and p-mTOR^Ser2448. i Glutamine deprivation in MIA PaCa-2 and PANC-1 cells reversed the mTOR activation induced by LAT2 OE. The data are presented as the mean ± SD. (Student’s t-test; *, P < 0.05)