Table 3.

Literature Overview

Source	Period	Stage	AC		SCC		Sign.	AC - SCC
			n	5y OS	n	5yOS
Early
Hopkins et al. [4]	1970–1985	I	124	0.6	370	0.9	X	−0.3
Shingleton et al. [30]	1984–1990	I	174	0.84	1136	0.84		0
Couvreur et al.a	2005–2015	IA-1B1	20	1	52	0.89		0.11
Teke et al. [8]	1996–2000	IA-IIB	33	0.77	218	0.73		0.04
Ayhan et al. [31]	1980–1997	IB	67	0.84	454	0.88		− 0.04
Eifel et al. [32]	1960–1989	IB	229	0.72	1538	0.81	X	− 0.09
Nakanishi et al. [34]	1976–1995	IB	104	0.88	405	0.96	X	−0.08
Galic et al. [3]	1998–2005	IB1	1094	0.85	3214	0.88		−0.03
Shimada et al. [6]	1997–2003	IB1	184	0.92	258	0.95		−0.03
Advanced
Galic et al. [3]	1998–2005	IB2	343	0.68	1701	0.69		−0.01
Shimada et al. [6]	1997–2003	IB2	39	0.76	67	0.74		0.01
Irie et al. [33]	1981–1996	IB-IIA	50	0.78	198	0.92		−0.14
Shimada et al. [6]	1997–2003	IB-IIB	280	0.87	540	0.83		0.04
Hopkins et al. [4]	1970–1985	II	40	0.47	186	0.62	X	−0.15
Shingleton et al. [30]	1984–1990	II	102	0.57	1073	0.67	X	−0.11
Galic et al. [3]	1998–2005	IIA	202	0.46	1488	0.58	X	−0.13
Shimada et al. [6]	1997–2003	IIA	11	0.55	83	0.87	X	−0.33
Galic et al. [3]	1998–2005	IIB	424	0.46	3754	0.55	X	−0.09
Katanyoo et al. [7]	1980–1997	IIB	85	0.72	170	0.71		0.01
Shimada et al. [6]	1997–2003	IIB	46	0.63	132	0.79	X	−0.16
Couvreur et al.a	2005–2015	IB2-IVA	16	0.88	91	0.63		0.25
Hopkins et al. [4]	1970–1985	III	25	0.08	114	0.36	X	−0.28
Shingleton et al. [30]	1984–1990	III	47	0.3	672	0.4		−0.1
Galic et al. [3]	1998–2005	IIIA	80	0.16	695	0.34	X	−0.18
Galic et al. [3]	1998–2005	IIIB	238	0.2	2568	0.31	X	−0.11
Katanyoo et al. [7]	1995–2008	IIIB-IVA	56	0.41	112	0.47		−0.06
Shingleton et al. [30]	1984–1990	IV	41	0.05	287	0.13		−0.08
Galic et al. [3]	1998–2005	IVA	82	0.08	622	0.17		−0.09
Galic et al. [3]	1998–2005	IVB	281	0.09	959	0.06		0.04

AC adenocarcinoma, SCC Squamous cell carcinoma, n number, 5yOS 5 year overall survival period: years of enrollment of patients, Sign significance with p-value < 0.05 (all significance levels lie between 0.01 and 0.05); AC-SCC: 5y survival data AC minus 5y survival data SCC resulting in a delta value

^acurrent article