Table. Characteristics of Studies Included in the Meta-analysis.

Source	No.	Age, y	Intervention	Rhinoplasty Surgeon's Approach	Follow-up Visits	Key Findings
						Intraoperative Bleeding	Eyelid Edema	Periorbital Ecchymosis	Thromboembolic Events
Beikaei et al,30 2015	96	16-42	Tranexamic acid: 10 mg/kg IV after anesthesia induction control: placebo solution	Open rhinoplasty	Not reported	Tranexamic acid was associated with a decrease in intraoperative bleeding	Not evaluated	Not evaluated	Not reported
Sakallioğlu et al,14 2015	50	20-36	Tranexamic acid: 1 g orally 2 h before surgery and 3 doses every 8 h after surgery for 5 d control: placebo solution	Open rhinoplasty	Days 1, 3, and 7	Tranexamic acid was associated with a decrease in intraoperative bleeding	Tranexamic acid reduced eyelid edema during the first postoperative week	Tranexamic acid reduced ecchymosis during the first postoperative week	Not reported
Eftekharian and Rajabzadeh,292016	50	16-40	Tranexamic acid: 1 g orally 2 h before surgery control: placebo solution	Not described		Tranexamic acid was associated with a decrease in intraoperative bleeding	Not evaluated	Not evaluated	Not reported
Ghavimi et al,16 2017	50	19-40	Tranexamic acid: 10 mg/kg IV immediately before surgery control: placebo solution	Closed rhinoplasty	Day 1	Tranexamic acid was associated with a decrease in intraoperative bleeding	Tranexamic acid reduced the eyelid edema	Tranexamic acid reduced ecchymosis	Not reported
Mehdizadeh et al,15 2018	30	18-39	Tranexamic acid: 10 mg/kg IV 1 h before surgery and 3 doses every 8 h after surgery control: placebo solution	Open rhinoplasty	Days 1, 3, and 7	Tranexamic acid was associated with a decrease in intraoperative bleeding	Tranexamic acid reduced eyelid edema during the first postoperative week	Tranexamic acid reduced ecchymosis during the first postoperative week	Not reported

Abbreviation: IV, intravenous.