Table 2. Univariate Analysis of the Association Between Perioperative RBC Transfusion and the Development of Postoperative VTE, DVT, or PEa.
| Perioperative RBC Transfusion | No. of Patients (N = 750 937) | Thrombolic Eventb | |||||
|---|---|---|---|---|---|---|---|
| VTE | DVT | PE | |||||
| No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | No. (%) | OR (95% CI) | ||
| Perioperative RBC transfusion | |||||||
| No | 703 527 | 4707 (0.7) | 1 [Reference] | 3141 (0.5) | 1 [Reference] | 1987 (0.3) | 1 [Reference] |
| Yes | 47 410 | 1602 (3.4) | 5.2 (4.9-5.5) | 1195 (2.5) | 5.8 (5.4-6.2) | 527 (1.1) | 4.0 (3.6-4.4) |
| Time of perioperative transfusion | |||||||
| None | 703 527 | 4707 (0.7) | 1 [Reference] | 3141 (0.5) | 1 [Reference] | 1987 (0.3) | 1 [Reference] |
| Preoperative only | 3605 | 105 (2.9) | 4.5 (3.7-5.4) | 88 (2.4) | 5.6 (4.5-6.9) | 30 (0.8) | 3.0 (2.1-4.3) |
| Intraoperative or postoperative only | 40 015 | 1295 (3.2) | 5.0 (4.7-5.3) | 940 (2.4) | 5.4 (5.0-5.8) | 452 (1.1) | 4.0 (3.6-4.5) |
| Preoperative and intraoperative or postoperative | 3790 | 202 (5.3) | 8.4 (7.2-9.7) | 167 (4.4) | 10.3 (8.8-12.0) | 45 (1.2) | 4.2 (3.2-5.7) |
Abbreviations: DVT, deep venous thrombosis; OR, odds ratio; PE, pulmonary embolism; RBC, red blood cell; VTE, venous thromboembolism.
a
Includes events within 30 d of a surgical procedure. Data were derived from the American College of Surgeons’ National Surgical Quality Improvement Program database for 2014.
b
Separate univariate models were used for each exposure-outcome association shown.