Table 2.
Proportion of continuers and initiators of blood pressure-interfering medications by hypertension cohort
| BP-interfering medication/class | Continuersa | Initiatorsb | ||
|---|---|---|---|---|
| Incident hypertension | Incident TRH | Incident hypertension | Incident TRH | |
| Any medication | 57.6 | 64.9 | 18.3 | 17.6 |
| Angiogenesis inhibitors | 72.9 | 82.1 | 26.4 | 23.0 |
| Antidepressants | 69.2 | 82.5 | 21.0 | 12.1 |
| Aspirin | 43.7 | 64.3 | 35.7 | 19.1 |
| Acetaminophen | 43.6 | 45.4 | 23.4 | 24.0 |
| Buspirone | 47.8 | 73.4 | 31.5 | 15.4 |
| Corticosteroids | 26.0 | 30.8 | 29.0 | 30.1 |
| ESAs | 31.1 | 71.7 | 39.6 | 19.1 |
| Hormones | 68.3 | 76.4 | 14.2 | 10.3 |
| Immunosuppressants | 49.7 | 67.2 | 25.7 | 16.8 |
| NSAIDs | 40.0 | 53.7 | 24.7 | 22.4 |
| Stimulants | 73.0 | 77.0 | 15.2 | 15.0 |
| Sympathomimetics | 18.6 | 22.4 | 27.0 | 28.9 |
Data are presented as % of users for the specific BP-interfering medication. Abbreviations: BP, blood pressure; ESAs, erythropoietin stimulating agents; NSAIDs, nonsteroidal anti-inflammatory drugs; TRH, treatment-resistant hypertension.
aPatients with at least one prescription refill after initiation of the cohort-defining antihypertensive drug (i.e., after the index date), among all patients with an initial fill of the respective BP-interfering medication during the pre-index period. The proportion of patients not continuing the interfering medication concurrently with antihypertensive intensification can be derived as 1—continuers. For example, 40% of the patients with incident hypertension who had a prescription fill of an NSAID before antihypertensive intensification continued that NSAID after antihypertensive intensification, whereas 60% did not continue the NSAID.
bPatients with an initial prescription fill of the respective BP-interfering medication after initiation of the cohort-defining antihypertensive drug, among all patients with at least one prescription fill of the respective BP-interfering medication. For example, 24.7% of the patients with incident hypertension with ≥1 prescription fill of an NSAID started that NSAID only after antihypertensive intensification.