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. 2018 Aug 9;31(12):1307–1316. doi: 10.1093/ajh/hpy127

Figure 1.

Figure 1.

Establishment of MetS in domestic pigs with RAS and changes in renal function and circulation compared to Normal and RAS alone. Intravenous glucose tolerance test showing increased HOMA-IR index in animals with the MetS-RAS compared with normal animals, suggesting insulin resistance (a). RBF and GFR significantly decreased in pigs with RAS, but not when RAS was accompanied by MetS (b, c). Representative multidetector- and micro-CT images showing collateral circulation (d), intrarenal cortical microvascular density and medullary vascular volume fraction (e), and their quantification (g, h). Collateral index was similarly elevated in RAS and MetS-RAS, but MetS-RAS had greater cortical microvascular loss (f). *P < 0.05 vs. normal, †P < 0.05 vs. RAS. Green arrow: coil inducing stenosis; red arrow: collateral vessels; orange arrow: vasa recta in medulla. (Please refer to color online only for indicated colors.) Abbreviations: CT, computed tomography; GFR, glomerular filtration rate; HOMA-IR, homeostasis model assessment of insulin resistance; MetS, metabolic syndrome; MetS-RAS, metabolic syndrome and renal artery stenosis; RAS, renal artery stenosis; RBF, renal blood flow.