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. 2018 Nov 9;14:3037–3051. doi: 10.2147/NDT.S175484

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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PPI network of DRTs and PRTs.

Notes: (A) PPI network with 32 DRTs as seeds. Pink nodes represent the 32 DRTs, blue nodes represent the proteins that have been reported to have interactions with the DRTs, and yellow nodes represent 245 PRTs with a DC value greater than twice the average. (B) PPI network of the 245 chosen PRTs, with nine DRTs (pink nodes).

Abbreviations: DC, degree centrality; DRTs, direct regulatory targets; PPI, protein–protein interaction; PRTs, possible regulatory targets.