Table 2.
Shared genes of putative FQD targets and AD-related genes (DRTs)
| Target/protein name | UniProt ID | Gene |
|---|---|---|
|
| ||
| ATP-binding cassette subfamily A member 1 | ABCA1_HUMAN | ABCA1 |
| Acetylcholinesterase | ACES_HUMAN | ACHE |
| Apolipoprotein E | APOE_HUMAN | APOE |
| Cholinesterase | CHLE_HUMAN | BCHE |
| Brain-derived neurotrophic factor | BDNF_HUMAN | BDNF |
| Voltage-dependent L-type calcium channel subunit α1S | CAC1S_HUMAN | CACNA1S |
| Calmodulin 1 | CALM_HUMAN | CALM1 |
| Caspase 3 | CASP3_HUMAN | CASP3 |
| C-C chemokine receptor type 2 | CCR2_HUMAN | CCR2 |
| Choline O-acetyltransferase | CLAT_HUMAN | CHAT |
| Neuronal acetylcholine receptor protein, α7 chain | ACHA7_HUMAN | CHRNA7 |
| Cytochrome C, somatic | CYC_HUMAN | CYCS |
| Cytochrome P450 2D6 | CP2D6_HUMAN | CYP2D6 |
| 24-Dehydrocholesterol reductase | DHC24_HUMAN | DHCR24 |
| Dual-specificity tyrosine-phosphorylation-regulated kinase 1A | DYR1A_HUMAN | DYRK1A |
| Glycogen synthase kinase 3β | GSK3B_HUMAN | GSK3B |
| Heme oxygenase 1 | HMOX1_HUMAN | HMOX1 |
| 5-Hydroxytryptamine 2A receptor | 5HT2A_HUMAN | HTR2A |
| Low-density-lipoprotein receptor | LDLR_HUMAN | LDLR |
| Low-density-lipoprotein receptor-related protein 8 | LRP8_HUMAN | LRP8 |
| Amine oxidase (flavin-containing) A | AOFB_HUMAN | MAOB |
| Microtubule-associated protein 2 | MTAP2_HUMAN | MAP2 |
| Mitogen-activated protein kinase 1 | MK01_HUMAN | MAPK1 |
| Mitogen-activated protein kinase 3 | MK03_HUMAN | MAPK3 |
| Microtubule-associated protein tau | TAU_HUMAN | MAPT |
| Nitric oxide synthase, inducible | NOS2_HUMAN | NOS2 |
| Nitric oxide synthase, endothelial | NOS3_HUMAN | NOS3 |
| Urokinase-type plasminogen activator | UROK_HUMAN | PLAU |
| Prostaglandin G/H synthase 2 | PGH2_HUMAN | PTGS2 |
| Sodium-dependent serotonin transporter | SC6A4_HUMAN | SLC6A4 |
| Tumor necrosis factor | TNFA_HUMAN | TNF |
| Very-low-density-lipoprotein receptor | VLDLR_HUMAN | VLDLR |
Abbreviations: FQD, Fuzheng Quxie Decoction; DRTs, direct regulatory targets.