Skip to main content
. Author manuscript; available in PMC: 2018 Nov 13.
Published in final edited form as: Annu Rev Microbiol. 2018 Jun 1;72:71–88. doi: 10.1146/annurev-micro-090817-062514

Figure 2.

Figure 2.

Models of potential fork-processing pathways downstream of a head-on collision. A head-on collision between replication (purple) and transcription (green) can lead to a reversed replication fork (left pathway), which is processed by RecBC (orange) and/or Ruv proteins (blue). These collisions can also result in RecA (red) loading (right pathway). RecBC processing may result in RecA loading, or RecA loading could result in initiation of replication fork reversal (dashed arrow). In both cases, replication restart occurs through Pri protein–mediated replisome reassembly.