Figure 2: Lack of genetic interaction between Daxx and the p53 pathway in vivo.

A) Schematic representation of radiosensitivity experiment. Mice were treated with a single sublethal (6 Gy) dose of ionizing radiation (IR) and monitored for evidence of morbidity due to enhanced radiosensitivity. B) Survival analysis of mice treated with 6 Gy IR. C) Survival analysis of Mdm2^Tg and Mdm2^TgDaxx^Δ3/+ mice. D) Tumor spectrum of mice from both genotypes. Tumors that were present in moribund mice are included in this analysis. No significant difference (Chi-squared p=0.50) in the proportions of different tumor types in Mdm2^TgDaxx^Δ3/+ compared to those expected from Mdm2^Tg controls. E) Representative histology of tumors from both groups, with lymphomas, sarcomas and hepatocellular carcinomas (HCCs) presented. Images are at 20x magnification.