Table 3. Multivariable Models for All-Cause and Cardiovascular Mortality.
| All-cause mortality | ||||||
|---|---|---|---|---|---|---|
| Unadjusted | Model 1* | Model 2** | ||||
|
HR (95% CI) |
p-value |
HR (95% CI) |
p-value |
HR (95% CI) |
p-value | |
|
Biomarkers elevated (referent is 0–1 elevated) |
||||||
| 2–3 biomarkers elevated |
1.31 (0.87, 1.99) |
0.20 |
1.19 (0.78, 1.80) |
0.42 |
1.35 (0.89, 2.05) |
0.16 |
| 4–6 biomarkers elevated |
2.51 (1.69, 3.72) |
<0.001 |
2.08 (1.40, 3.10) |
<0.001 |
2.47 (1.66, 3.66) |
<0.001 |
| 7 biomarkers elevated |
3.36 (2.02, 5.57) |
<0.001 |
2.12 (1.24, 3.64) |
0.006 |
2.56 (1.50, 4.38) |
<0.001 |
|
Biomarkers elevated (per additional biomarker elevated) |
1.24 (1.17, 1.32) |
<0.001 |
1.17 (1.10, 1.25) |
<0.001 |
1.21 (1.14, 1.29) |
<0.001 |
| Cardiovascular mortality | ||||||
| Unadjusted | Model 1* | Model 2** | ||||
|
HR (95% CI) |
p-value |
HR (95% CI) |
p-value |
HR (95% CI) |
p-value | |
|
Biomarkers elevated (referent is 0–1 elevated) |
||||||
| 2–3 biomarkers elevated |
1.87 (0.90, 3.89) |
0.09 |
1.70 (0.81, 3.56) |
0.16 |
1.89 (0.91, 3.94) |
0.09 |
| 4–6 biomarkers elevated |
2.78 (1.38, 5.63) |
0.004 |
2.24 (1.09, 4.58) |
0.03 |
2.68 (1.32, 5.44) |
0.007 |
| 7 biomarkers elevated |
6.11 (2.74, 13.62) |
<0.001 |
3.82 (1.63, 8.94) |
0.002 |
5.01 (2.13, 11.78) |
<0.001 |
|
Biomarkers elevated (per additional biomarker elevated) |
1.29 (1.17, 1.42) |
<0.001 |
1.20 (1.08, 1.33) |
<0.001 |
1.25 (1.13, 1.39) |
<0.001 |
*
Model 1 adjusts for NYHA class (III/IV vs. I/II) and the Parsonnet score.
**
Model 2 adjusts for NYHA class (III/IV vs. I/II) and the EuroSCORE 2.
Abbreviations: HR, hazard ratio; CI, confidence interval.