Table 1:

Performance of heart failure computable phenotype algorithms compared to validated heart failure in Olmsted County, Minnesota, 2010–2012 (N=76,254)

		Sensitivity		Specificity		PPV		NPV
Algorithm		Rate	%	Rate	%	Rate	%	Rate	%
1	≥1 HF code*	1733/2 201	78. 7	73257/74 053	98. 9	1733/25 29	68. 5	73257/7 3725	99. 4
2	≥1 HF code + any HF medication†	1479/2 201	67. 2	73485/74 053	99. 2	1479/20 47	72. 3	73485/7 4207	99. 0
3	≥1 HF code + any HF medication + elevated NT- proBNP‡	1018/2 201	46. 3	735837/74 053	99. 7	1018/12 34	82. 5	73837/7 5020	98. 4
4	≥2 HF codes	1357/2 201	61. 7	73698/74 053	99. 5	1357/17 12	79. 3	73698/7 4542	98. 9
5	≥2 HF codes + any HF medication	1234/2 201	56. 1	73757/74 053	99. 6	1234/15 30	80. 7	73757/7 4724	98. 9
6	≥2 HF codes + any HF medication + elevated NT- proBNP	916/22 01	41. 6	73910/74 053	99. 8	916/105 9	86. 5	73910/7 4077	98. 3
7	≥1 inpatient or ≥2 outpatient HF codes	1614/2 201	73. 3	73490/74 053	99. 2	1614/21 77	74. 1	73490/7 4077	99. 2
8	≥1 inpatient or ≥2 outpatient HF codes + any HF medication	1386/2 201	63. 0	73638/74 053	99. 4	1386/18 01	77. 0	73638/7 4453	98. 9
9	≥1 inpatient or ≥2 outpatient HF codes + any HF medication + elevated NT- proBNP	1000/2 201	45. 4	73870/74 053	99. 8	1000/11 83	84. 5	73870/7 5071	98. 4

^*Heart failure code is International Classification of Diseases – 9^th Revision, Clinical Modification code 428.

^†Heart failure medications include aldosterone antagonists (eplerenone, spironolactone), HF specific beta blockers (bisoprolol, carvedilol, metoprolol succinate), loop diuretics (bumetanide, ethacrynic acid, furosemide, torsemide), digoxin, angiotensin converting enzyme inhibitors and angiotensin receptor blockers.

^‡Elevated NT-proBNP criteria defined as >450 pg/mL; those who did not have NT-proBNP measured or had NT-proBNP <450 pg/mL did not meet this criteria.

HF, heart failure; NPV, negative predictive value; PPV, positive predictive value.