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. 2018 Aug 1;154(10):1145–1151. doi: 10.1001/jamadermatol.2018.2312

Table 1. Therapeutic Hair Regrowth Outcomes of Contact Immunotherapy in Patients With Alopecia Areataa.

Sensitizer and AA Subtype Any Regrowth Minor Regrowth Major Regrowth Complete Regrowth
Response Rate, % (95% CI) No. of Studies (No. of Patients) Response Rate, % (95% CI) No. of Studies (No. of Patients) Response Rate, % (95% CI) No. of Studies (No. of Patients) Response Rate, % (95% CI) No. of Studies (No. of Patients)
Diphenylcyclopropenone
PA 75.5 (67.6-82.0) 8 (248) 63.7 (55.1-71.6) 15 (315) 55.4 (41.4-68.7) 12 (322) 41.6 (27.9-56.8) 13 (311)
AT/AU 51.6 (42.0-61.1) 9 (193) 45.0 (35.1-55.2) 14 (279) 28.3 (22.4-35.0) 12 (326) 22.0 (15.2-30.6) 13 (366)
Overall 63.8 (55.0-71.7) 9 (441) 54.5 (47.2-61.6) 16 (594) 38.9 (29.2-49.6) 13 (648) 30.7 (22.9-39.6) 13 (677)
Squaric acid dibutyl ester
PA 74.2 (60.8-84.3) 7 (211) 66.5 (50.2-79.6) 6 (106) 51.8 (37.4-65.8) 6 (120) 50.5 (17.2-83.4) 4 (60)
AT/AU 61.5 (45.5-75.4) 7 (92) 45.0 (22.4-69.9) 6 (78) 25.0 (16.5-36.0) 6 (79) 35.0 (18.6-55.9) 5 (77)
Overall 67.8 (57.8-76.5) 7 (303) 57.9 (43.2-71.3) 7 (184) 38.4 (27.5-50.6) 7 (199) 38.4 (23.1-56.5) 5 (137)
Overall
PA 74.6 (67.9-80.3) 15 (459) 64.9 (57.7-71.6) 20 (409) 56.1 (45.9-65.8) 18 (430) 42.6 (29.9-56.3) 17 (371)
AT/AU 54.5 (46.2-62.6) 16 (285) 45.0 (35.9-54.4) 20 (357) 28.7 (24.1-33.8) 18 (405) 24.9 (18.2-33.0) 18 (443)
Overall 65.5 (59.1-71.3) 16 (744) 55.5 (49.0-61.9) 22 (766) 39.4 (31.8-47.6) 19 (835) 32.3 (25.3-40.2) 18 (814)

Abbreviations: AA, alopecia areata; AT, alopecia totalis; AU, alopecia universalis; PA, patchy alopecia.

a

Any regrowth was less than 10% of hair loss; minor regrowth, 10% to 59%; major regrowth, 60% to 89%; and complete regrowth, 90% to 100%.