Table 2. Genes Included in the Diagnostic Signature.
| Gene Symbol | Gene Name | HGNC Identification No. | Probe Identification No. | Location | Logistic Regression Coefficienta |
|---|---|---|---|---|---|
| CACNA1E | Calcium voltage-gated channel subunit alpha1 E | 1392 | 7510647 | 1q25.3 | 0.955 |
| DDIAS | DNA damage–induced apoptosis suppressor | 26351 | 2570019 | 11q14.1 | 0.844 |
| KLHL2 | Kelch-like family member 2 | 6353 | 1070593 | 4q32.3 | 0.789 |
| PYROXD2 | Pyridine nucleotide-disulphide oxidoreductase domain 2 | 23517 | 1684497 | 10q24.2 | 0.727 |
| SMOX | Spermine oxidase | 15862 | 270068 | 20p13 | 0.675 |
| ZNF185 | Zinc finger protein 185 with domain | 12976 | 6840674 | Xq28 | 0.646 |
| LINC02035 | Long intergenic non–protein coding RNA 2035 | 52875 | 3236239 | 3q21.1 | 0.561 |
| CLIC3 | Chloride intracellular channel 3 | 2064 | 5870136 | 9q34.3 | 0.464 |
| S100P | S100 calcium-binding protein P | 10504 | 1510424 | 4p16.1 | −0.405 |
| IFI27 | Interferon alpha–inducible protein 27 | 5397 | 3990170 | 14q32.12 | −0.426 |
| HS.553068 | BX103476 NCI_CGAP_Lu5 Homo sapiens cDNA clone | NA | 1470450 | NA | −0.599 |
| CD163 | CD163 molecule | 1631 | 2680092 | 12p13.31 | −0.638 |
| RTN1 | Reticulon 1 | 10467 | 6860193 | 14q23.1 | −0.690 |
Abbreviations: cDNA, complementary DNA; HGNC, Hugo Gene Nomenclature Committee; NA, not applicable.
a
The logistic regression coefficient indicates the power of the gene to discriminate Kawasaki disease in the parallel regularized regression model search. Genes with positive values show increased expression in Kawasaki disease relative to other diseases, and genes with negative values show decreased expression in Kawasaki disease.