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. 2018 Jun 14;4(10):1335–1343. doi: 10.1001/jamaoncol.2018.1778

Figure 4. Treatment Interactions.

Figure 4.

A and B, Weighted cumulative incidence curves demonstrating the prognostic effect of letrozole or tamoxifen monotherapy on the risk of distant recurrence by PIK3CA mutation status. Number of events indicates the observed number of distant recurrences per subgroup. The 5-year estimates for distant recurrence and 95% CIs were calculated with the use of sampling weights. C, Hazard ratio (HR) for letrozole monotherapy vs tamoxifen monotherapy according to PIK3CA mutation status. These data were derived with a weighted univariate Cox proportional hazards regression model. The interaction P value represents the interaction between PIK3CA mutation status and treatment benefit. The observed number of patients (number of events) was 114 (24) for the PIK3CA mutation-positive group and 184 (47) for PIK3CA mutation-negative group.