Table 2. Logistic Regression Analysis of Microvascular Invasion Presence in Patients Receiving Antiviral Treatment (AVT) and Those Not Receiving AVT (N = 2362).
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Age, y (continuous) | 0.989 (0.981-0.997) | .005 | NA | NA |
| Sex, male vs female | 1.176 (0.939-1.473) | .16 | NA | NA |
| Diabetes, yes vs no | 0.887 (0.680-1.156) | .37 | NA | NA |
| HBeAg, positive vs negative | 1.064 (0.893-1.267) | .49 | NA | NA |
| HBeAb, positive vs negative | 0.850 (0.709-1.020) | .08 | NA | NA |
| HBV DNA level, ≥2000 vs <2000 IU/mL | 1.462 (1.243-1.720) | <.001 | 1.409 (1.171-1.696) | <.001 |
| AVT, yes vs no | 0.667 (0.525-0.847) | .001 | 0.758 (0.575-0.998) | .049 |
| ALT level, >44 vs ≤44 U/L | 0.877 (0.743-1.035) | .12 | NA | NA |
| AST level, >40 vs ≤40 U/L | 1.360 (1.155-1.603) | <.001 | NA | NA |
| GGT level, >64 vs ≤64 U/L | 1.221 (1.039-1.436) | .02 | NA | NA |
| TBIL level, >0.99 vs ≤0.99 mg/dL | 1.007 (0.837-1.213) | .94 | NA | NA |
| Albumin level, <3.5 vs ≥3.5 g/dL | 0.777 (0.514-1.174) | .23 | NA | NA |
| PT, >13 vs ≤13 s | 1.004 (0.811-1.244) | .97 | NA | NA |
| Platelet count, <100 vs ≥100 ×103/μL | 0.851 (0.697-1.041) | .12 | NA | NA |
| Glucose level, >126.13 vs ≤126.13 mg/dL | 0.764 (0.550-1.063) | .11 | NA | NA |
| Creatinine level, >1.18 vs ≤1.18 mg/dL | 0.526 (0.237-1.167) | .11 | NA | NA |
| WBC count, <4000/μL vs ≥4000/μL | 0.867 (0.712-1.055) | .16 | NA | NA |
| Hemoglobin, g/L (continuous) | 1.000 (0.995-1.005) | <.99 | NA | NA |
| α-Fetoprotein level, >400 vs ≤400 ng/mL | 2.538 (2.133-3.019) | <.001 | 1.736 (1.431-2.106) | <.001 |
| Blood loss, >800 vs ≤800 mL | 1.509 (1.046-2.177) | .03 | NA | NA |
| Transfusion, yes vs no | 1.453 (1.124-1.879) | .004 | NA | NA |
| Surgical margin, <1 vs ≥1 cm | 1.049 (0.865-1.272) | .63 | NA | NA |
| Tumor diameter, cm (continuous) | 1.089 (1.064-1.114) | <.001 | 1.043 (1.015-1.072) | .002 |
| Tumor No., multiple vs single | 1.235 (0.956-1.596) | .11 | NA | NA |
| Tumor encapsulation, incomplete vs complete | 3.151 (2.661-3.730) | <.001 | 2.458 (2.048-2.951) | <.001 |
| Satellite nodules, presence vs absence | 2.672 (2.118-3.371) | <.001 | 1.832 (1.416-2.370) | <.001 |
| Edmondson-Steiner grade,36 III/IV vs I/II | 4.103 (3.391-4.963) | <.001 | 2.947 (2.388-3.637) | <.001 |
| Cirrhosis, yes vs no | 1.356 (1.152-1.595) | <.001 | 1.929 (1.590-2.339) | <.001 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, λ-glutamyltransferase; HBeAb, hepatitis B e antibody; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; NA, not applicable; OR, odds ratio; PT, prothrombin time; TBIL, total bilirubin; WBC, white blood cell.
SI conversion factor: To convert ALT to microkatals per liter, multiply by 0.0167; AST to microkatals per liter, multiply by 0.0167; GGT to microkatals per liter, multiply by 0.0167; TBIL to micromoles per liter, multiply by 17.104; albumin to grams per liter, multiply by 10; platelet count to ×109/L, multiply by 1; glucose to millimoles per liter, multiply by 0.0555; creatinine to micromoles per liter, multiply by 88.4; WBC count to ×109/L, multiply by 0.001; α-fetoprotein to micrograms per liter, multiply by 1.