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. 2018 Jun 14;75(10):995–1002. doi: 10.1001/jamapsychiatry.2018.1831

Figure 2. Mean Cigarettes per Day (CPD) at Baseline and End of Study .

Figure 2.

Baseline was 2 weeks before randomization, and weeks 9 to 10 was the end of the study. Observed data are plotted (mean [SE]). Baseline data (own-brand cigarettes provided gratis) are based on observed data, and data for weeks 9 to 10 are based either on observed data (participants not lost to observation) or monotone multiple imputation of missing CPD. Analysis of imputed data indicated that, while controlling for baseline CPD, the very low-nicotine-content cigarettes (VLNCC) group reduced their CPD significantly more than the normal-nicotine-content cigarettes (NNCC) group during the 10-week postrandomization period (P < .001). Mean decrease among VLNCC participants was 1.51 CPD (95% CI, 0.86-2.17) more than NNCC participants. Analysis of observed data showed substantively the same effect (P < .001). Mean decrease among VLNCC participants was 1.64 CPD (95% CI, 0.93-2.35) more than NNCC participants.