Figure. Single-Nucleotide Polymorphisms Associated With Bleeding Risk in the African American Discovery Cohort.

A, Single-nucleotide polymorphisms (SNPs) are plotted on the x-axis according to their positions on each chromosome against association with warfarin-associated bleeding on the y-axis (−log₁₀ P value). The red line shows genome-wide significant threshold of P = 1.62 x 10⁻⁸. Green points toward the top of graph indicate the near-significant association found in chromosome 6.

B, The colors of the circles denote linkage disequilibrium (r2) between rs78132896 (purple diamond) and nearby SNPs (based on pairwise r² values from the 1000 Genomes Project African population). The 3 near-significant SNPs in high linkage disequilibrium with rs78132896 are shown. The blue line and right y-axis show the estimated recombination rate (obtained from HapMap). The x-axis represents the genomic position in chromosome 6 and the left y-axis represents the –log₁₀ P of association with warfarin-related bleeding in the discovery cohort (n = 215). Genes at this locus are indicated in the lower panel of the plot. Chromosomal positions are based on hg19 genome build.