Figure 2. Association Between Natriuretic Peptide (NP) Levels and Incidence of Primary Outcome in 6 Subgroups of the Americas Region of the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial.

Restricted cubic splines models with 3 knots were constructed to display the association between log-transformed, standardized NP concentrations as a continuous variable and the incidence of the primary end point for each of the key subgroups. The dotted lines reflect the 95% confidence intervals. BNP indicates B-type natriuretic peptide; eGFR, estimated glomerular filtration rate; NT-proBNP, N-terminal pro-B-type natriuretic peptide. Body mass index is calculated as weight in kilograms divided by height in meters squared.