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. 2018 Aug 2;136(10):1115–1120. doi: 10.1001/jamaophthalmol.2018.2986

Table. Calculated Mutation Rate for Uveal Melanomas With Different Thicknesses Based on the 5-Year Metastasis Rate Published by Shields et al6.

Thickness, mm Cells in Tumor Mass, No. 5-y Metastasis Rate, % Mutation Rate
0-1.0 7.25 × 106 5.70 7.86 × 10−7
1.1-2.0 6.07 × 107 7.90 1.30 × 10−7
2.1-3.0 1.56 × 108 4.60 2.94 × 10−8
3.1-4.0 2.82 × 108 8.10 2.87 × 10−8
4.1-5.0 4.25 × 108 15.20 3.57 × 10−8
5.1-6.0 5.75 × 108 17.30 3.01 × 10−8
6.1-7.0 9.72 × 108 15.20 1.56 × 10−8
7.1-8.0 1.18 × 109 21.30 1.80 × 10−8
8.1-9.0 1.37 × 109 31.10 2.27 × 10−8
9.1-10.0 2.62 × 109 30.70 1.17 × 10−8
>10.0 3.46 × 109 40.20 1.16 × 10−8