Figure 2. Randomized Clinical Trials of Levothyroxine Therapy in Subclinical Hypothyroidism Outcomes on Cognitive Function.

MMSE indicates Mini Mental State Examination. Mean values of the cognition scale per study group are shown in eTable 2 in Supplement 1. Weights are derived from a fixed-effects meta-analysis of standardized mean differences. Sizes of data markers indicate weight of studies. Dashed vertical line represents overall mean effect. All effect sizes are standardized. Standardized mean differences of 0.2, 0.5, and 0.8 correspond to small, moderate, and large clinical effects, respectively.⁵⁵ See Table for descriptions of outcome scales. Numbers differ between participants randomized and participants with available outcome data in the studies by Jorde et al²⁶ and Stott et al¹² (see Table and eTable 2).