Table 3. Sensitivity Analysesa.
| Percentage Change (95% CI) |
|||
|---|---|---|---|
| Model | No. | Cord Blood Telomere Length | Placental Telomere Length |
| Main model | 641 | −8.8 (−14.1 to −3.1) | −13.2 (−19.3 to −6.7) |
| Unconstrained lag structure | 641 | −8.4 (−14.0 to −2.5) | −14.0 (−20.2 to −7.3) |
| Additional adjustment for month of delivery | 641 | −9.2 (−14.6 to −3.4) | −12.3 (−18.6 to −5.6) |
| Excluding non-European mothers | 567 | −8.7 (−14.4 to −2.6) | −11.9 (−18.6 to −4.8) |
| Excluding mothers with low educational level | 570 | −10.0 (−15.4 to −4.1) | −13.4 (−19.8 to −6.4) |
| Excluding current and former smokers | 401 | −12.1 (−18.8 to −4.9) | −16.2 (−23.5 to −8.2) |
| Excluding mothers with pregnancy complications | 568 | −9.1 (−14.7 to −3.2) | −14.3 (−20.7 to −7.4) |
| Excluding cesarean deliveries | 617 | −8.7 (−14.1 to −2.9) | −12.8 (−19.0 to −6.1) |
| Excluding all of the above | 281 | −14.0 (−21.9 to −5.2) | −13.3 (−22.3 to −3.2) |
Abbreviations: BMI, body mass index; PM2.5, particulate matter with an aerodynamic diameter of 2.5 μm or less.
a
Estimates provided as a cumulative (weeks 1-40) percentage change in mean relative telomere length for a 5-μg/m3 increment in PM2.5. Models were adjusted for date of delivery, gestational age, maternal BMI, maternal age, paternal age, newborn sex, newborn ethnicity, season of delivery, parity, maternal smoking status, maternal educational level, pregnancy complications, and ambient temperature. The season of delivery was removed from the model adjusting for month of delivery.