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. Author manuscript; available in PMC: 2019 Oct 17.
Published in final edited form as: Nat Prod Rep. 2018 Oct 17;35(10):1029–1045. doi: 10.1039/c8np00040a

Fig. 2.

Fig. 2.

The central role of ACP in type II FAS and PKS pathways. Here, the actinorhodin type II PKS biosynthetic proteins in Streptomyces coelicolor are evolutionarily derived from type II FAS. Despite these similarities, the pathways remain isolated from each other – they do not scramble or exchange intermediates to provide chimeric products. This inherent fidelity, as well as known cross-reactivities, remains an important challenge to understanding and eventually reprogramming these pathways. ACP = acyl carrier protein; KS = β-ketoacyl-ACP synthase; MAT = malonylacyltransferase; KR = β-ketoacyl-ACP-reductase; DH = β-hydroxyacyl-ACP dehydratase; ER = enoyl reductase; AT/TE = acyltransferase/thioesterase; KS-CLF = ketosynthase-chain length factor; AR = aromatase; CYC-TE = cyclase-thioesterase.