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ACP sequestration of elongating intermediates. ACPs from both type II FAS and PKS pathways have been shown to sequester intermediates within the hydrophobic cavity at the center of the four-helix bundle. (A) E. coli heptanoyl-AcpP (PDB: 2FAD).27 (B) S. coelicolor octanoyl-actACP (PDB: 2KGC).28 (C) S. coelicolor actACP with tethered probe 11, based on NMR (Fig. 9B) and in silico docking.29
