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Probes for the investigation of PPIs. (A) Mechanism-based crosslinking probes. X = pantetheine analog; R = carbon chain. (B) The tight-binding probe for ER. Y = linker. (C) The BMOE probe. (D) Sulfonyl-3-alkynyl pantetheinamide undergoes chemoenzymatic one pot reaction and crosslink reaction to form crosslinked complex with DH.
