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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Differentiation. 2018 Sep 6;103:46–65. doi: 10.1016/j.diff.2018.09.001

Figure 16.

Figure 16.

Xenografts of twin 13-week human female reproductive tracts grown for 4 weeks in untreated ovariectomized (A, B & D) and ovariectomized DES-treated athymic mice (C & E). Note in (A–B) uniform strong ESR1 immunostaining of the tubal epithelium in the untreated ovariectomized host, and (C) the mixture of weakly ESR1positive and ESR1-negative tubal epithelial cells in the DES-treated specimen. Sections (B & D) depict the uterine corpus of a xenograft grown in an untreated ovariectomized host. The epithelium of the uterine corpus is ESR1-negative, while the uterine mesenchyme is ESR1-reactive. Section (E) depicts the uterine corpus of the twin 13week specimen grown in a DES-treated ovariectomized host. Note the strong uniform expression of ESR1 in the uterine epithelium. Note also the substantial DES-induced plication of the uterine tube (compare B & C), and the profound DES-induced uterine gland formation (compare (B & E).