Table 2.

Characteristics of dogs enrolled in the Lipocurc clinical study.

ID	Age	Sex	Breed	Diagnosis at enrollment	No. doses	Toxicity	Response at 28 days
1	7	FS	Belgian Malinois	Presumed metastasis from appendicular OSA	2	Grade 1 normocytic, hypochromic, non-regenerative anemia 7 days after 2nd dose.	N/A
2	5	MC	Mixed breed	Presumed metastasis from chest wall sarcoma	1	None reported (decreasing HCT)	N/A
3	5	MC	Golden retriever	Cytology consistent with metastasis from perianal high grade PNST	4	None reported (decreased HCT)	Stable (1 lesion)
4	13	FS	Border Collie	Primary pulmonary carcinoma	4	Grade 2 AST elevation	Stable (2 lesions)
5	10	FS	Wirehaired fox terrier	Cytology consistent with primary pulmonary carcinoma	0	N/A	N/A
6	12	MC	Labrador	Presumed metastasis from a historical primary thyroid carcinomaa	4	None, static mild non-regenerative anemia	Stable (2 lesions)
7	12	MC	English Cocker	Presumed metastasis from oral malignant melanoma	4	Grade 1 regenerative anemia after last dose	Progressive (2 lesions)
8	9	FS	Mixed breed	Presumed metastasis from eccrine carcinoma on digit	1	Died at home the day after infusion following an acute progression of respiratory signs.	N/A
9	10	FS	Ridgeback	Cytology consistent with primary pulmonary carcinoma	4	Grade 2 vomiting	Stable (1 lesion)
10	8	F	American Cocker Spaniel	Presumed metastasis from multiple mammary tumors	4	Intermittent grade 1 regenerative anemia during treatment. Grade 2 allergic reaction during 4th infusion.	Lung nodule not detected at recheck.b
11	11	FS	Golden Retriever	Presumed metastasis from mammary carcinoma	1	Became progressively weaker after infusion. Euthanized 2 days post treatment.	N/A

FS- Female spayed; MC- Male castrated; F- Female

^aIdentified as a bronchiolar adenoma upon histologic interpretation at necropsy.

^bThe pulmonary lesion detected at baseline may have been superimposition of normal structures upon review. No change in the size of the primary mammary tumors was observed throughout the study period.