Table 1.
Composition of available prothrombin complex concentrates
| Product (Manufacturer) |
Coagulation factor content (IU) | Antithrombotic content (IU) | |||||
|---|---|---|---|---|---|---|---|
| II | VII | IX | X | Protein C | Protein S | ATIII | |
| Beriplex P/N (CSL Behring) |
400–960 | 200–500 | 400–620 | 440–1200 | 300–900 | 240–760 | 4–30 |
| Octaplex (Octapharma) |
280–760 | 180–480 | 500 | 360–600 | 260–620 | 240–640 | 0 |
| Prothromplex Total (Shire/Baxalta) |
480–900 | 500 | 600 | 600 | 400 | Not declared | Not declared |
| Cofact/PPSB SD/Kanokad (Sanquin/CAF) |
280–700 | 140–400 | 500 | 280–700 | 222–780 | 20–160 | ≤0.6 |
| Uman Complex (Kedrion) |
500 | Not declared | 500 | 400 | Not declared | Not declared | 2.5 |
| Profilnine (Grifols) |
150 | 35 | 100 | 100 | Not declared | Not declared | Not declared |
| Bebulin (Shire/Baxalta) |
Not declared |
Not declared (low) | Not declared | Not declared | Not declared | Not declared | Not declared |
| FEIBA (Shire/Baxalta) |
Present* mainly non- activated |
Present* activated |
Present* mainly non- activated |
Present,* mainly non- activated |
Not declared |
Not declared | Not declared |
ATIII, antithrombin III. Data are based on the prescribing information of each product, as of January 2017.
*
Indicates that values are not provided in the prescribing information, just the presence or absence of the coagulation factor