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. Author manuscript; available in PMC: 2019 Sep 4.
Published in final edited form as: Differentiation. 2018 Sep 4;103:24–45. doi: 10.1016/j.diff.2018.08.005

Figure 17.

Figure 17.

Xenografts of right and left halves of a 14-week human fetal prostate grown for 4 weeks in castrated male athymic mice treated with a 20mg pellet of dihydrotestosterone (DHT) or untreated control (sham) as indicated. For TP63 and keratins 7, 8 and 19 the status of epithelial differentiation is advanced in DHT-treated specimens (Al-El)versus androgen-deficient control specimens (A2-E2). Patterning of α-actin-positive smooth muscle is also affected by DHT (El versus E2). S100-positive ganglia and nerve fibers were seen in both DHT-treated and control grafts (F1-F2). Scale bar in (D1 -D2) applies to (A-C).