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Xenograft of a 12-week human fetal female urethra grown for 8 weeks in a castrated DHT-treated host (A-C) immunostained for KRT19, KRT7 and TP63 as indicated. Xenografts of a 13-week human fetal female urethra grown for 8 weeks in a castrated DHT-treated host (D-F) immunostained for KRT19, KRT7 and TP63 as indicated. Arrows in (C)) depict pockets of TP63-negative epithelial cells in areas of incipient canalization.
