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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: ACS Chem Biol. 2018 May 17;13(6):1474–1479. doi: 10.1021/acschembio.8b00262

Figure 2. Design and localization of a UPRT enzyme construct to mitochondria.

Figure 2.

A. Schematic of proposed UPRT-mediated RNA synthesis in the mitochondria. B. Design of a mitochondria-targeted UPRT construct. C. Imaging of the mitochondria-targeted UPRT construct displays overlap with a Mito-RFP construct. Hoechst stains nuclear DNA.